NCT05480020

Probiotic Toothpaste for Microbial Colonization

Colonisation Efficacy of Streptococcus Salivarius M18 Toothpaste

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: John Hale · Industry
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate the colonization efficacy of probiotic toothpastes in healthy adults

Detailed description

This is a double blind randomized controlled study with no cross over to evaluate the colonization efficacy of toothpaste containing a commercially available probiotic bacterium Streptococcus salivarius M18. Participants will be randomly assigned to one of the 3 groups for brushing teeth with a probiotic toothpaste containing different doses of Streptococcus salivarius M18 over a seven day period. Saliva samples will be collected at predetermined time points pre and post intervention. Colonization efficacy will be determined by enumerating the probiotic in the saliva samples using standard microbiological techniques.

Conditions

• Microbial Colonization

Interventions

Type	Name	Description
OTHER	Streptococcus salivarius M18 toothpaste	Probiotics Streptococcus salivarius M18 toothpaste 1 million cfu/g In this study, a toothpaste formulation containing S. salivarius M18 will be evaluated for its potential for delivering the probiotic to the oral cavity.
OTHER	Streptococcus salivarius M18 toothpaste	Probiotics Streptococcus salivarius M18 toothpaste 10 million cfu/g In this study, a toothpaste formulation containing S. salivarius M18 will be evaluated for its potential for delivering the probiotic to the oral cavity.
OTHER	Streptococcus salivarius M18 toothpaste	Probiotics Streptococcus salivarius M18 toothpaste 100 million cfu/g In this study, a toothpaste formulation containing S. salivarius M18 will be evaluated for its potential for delivering the probiotic to the oral cavity.

Timeline

• Start date: 2022-08-01
• Primary completion: 2022-09-01
• Completion: 2022-10-01
• First posted: 2022-07-29
• Last updated: 2022-07-29

Locations

1 site across 1 country: New Zealand