NCT05478330

Evaluation of Efficacy of Topical Flutamide in the Treatment of Acne Vulgaris

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 16 Years – 40 Years
• Healthy volunteers: Accepted

Summary

From the obtained results, topical Flutamide 1% gel can be a promising, effective, and safe alternative in treating patients with acne vulgaris with minimal side effects.

Detailed description

Flutamide is a non-steroidal anti-androgen, which is used to treat patients with prostate cancer. Due to its anti-androgenic properties can be used in cases of acne, hirsutism, and androgenic alopecia with successful outcomes. To minimize the unnecessary systemic side effects associated with the oral administration of Flutamide. It has been shown that the topical delivery of Flutamide can allow high drug levels at the site of action, decreasing the systemic side effects and improving patient compliance. The Flutamide group received topical Flutamide 1% gel twice daily on the face for 8 weeks and the control group received the same gel components, without flutamide, twice daily on the face for 8 weeks

Conditions

• Acne Vulgaris Superficial Mixed Comedonal and Inflammatory

Interventions

Type	Name	Description
DRUG	Flutamide 1% gel	Group A: Flutamide-treated patients: Consisted of 25 patients with acne vulgaris treated with 1% Flutamide topical gel on the face two times per day for a duration of 8 weeks.
DRUG	topical gel without flutamide	Group B: Consisted of 25 patients with acne vulgaris treated with topical gel with the same component as the other group, except for flutamide, on the face twice per day for a duration of 8 weeks.

Timeline

• Start date: 2021-01-13
• Primary completion: 2022-06-30
• Completion: 2022-06-30
• First posted: 2022-07-28
• Last updated: 2022-07-28

Locations

1 site across 1 country: Egypt