Trials / Completed
CompletedNCT05477875
Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control
Randomized, Controlled Cross-over Comparison of Cannabinoid to Oral Opioid for Postoperative Photorefractive Keratectomy Pain Control
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 35 (actual)
- Sponsor
- University of Florida · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
Photorefractive Keratectomy (PRK) is a commonly performed corneal refractive surgery but has significant post-operative pain. Pain medications after PRK are typically opioid-acetaminophen combinations. Alternatives to opioid medication are worth consideration. Patients will receive PRK in each eye sequentially, using the cannabinoid or codeine/acetaminophen for one eye and the other treatment for the fellow eye two weeks later.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | oral cannabinoid | dronabinol |
| COMBINATION_PRODUCT | oral codeine/acetaminophen | 10 tablets of acetaminophen-codeine combination (300-30mg) without refills. |
Timeline
- Start date
- 2024-02-01
- Primary completion
- 2025-01-22
- Completion
- 2025-01-22
- First posted
- 2022-07-28
- Last updated
- 2025-08-07
- Results posted
- 2025-08-07
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT05477875. Inclusion in this directory is not an endorsement.