NCT05475951

Gasdermin-D and Pannexin-1 in Pregnancy

Investigation of Gasdermin-D and Pannexin-1 in Fat and Placental Tissues in Pregnant Women With Obesity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 79 (actual)
• Sponsor: Haseki Training and Research Hospital · Academic / Other
• Sex: Female
• Age: 20 Years – 35 Years
• Healthy volunteers: Accepted

Summary

One -third of fertile women around the world are overweight or obese. This means increasing risk for both the mother and the child. Fat tissue is a factor in gestational DM development and the increase in material inflammation and oxidative stress. According to new knowledge, it is an important need to examine molecules that are not handled in new and human research in these mechanisms in fat and placenta tissues in obesity. For this purpose, the examination of the expression of gasdermin-D and pannex-1 proteins, which are shown to be produced in the cells of both tissues, is worth investigating in human fat tissue and placenta. Gasdermins and pannexins are proteins intersecting by interacting in cellular functions. Gasdermins cause piroptosis, a type of litic proinflammatory cell death. Pannexin-1 plays in various cellular functions, including inflammation. These are examined in a small number of in vitro studies in material fat tissue and placenta, and the design of this study in people whose applications are applied is original in humans. The status of the expressions of the gasdermin-D and pannexin-1 proteins, which will be examined for the first time in obese pregnant women's fat and placental tissues, are the subject of this research with each other and their relationship with other maternal and neonatal data.

Conditions

• Pregnancy Complications
• Maternal Obesity

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Biomarker measurement of pannexin-1 and gasdermin-D	These biomarkers were measured in the placental and adipose tissues of the participants.

Timeline

• Start date: 2021-12-01
• Primary completion: 2022-05-15
• Completion: 2022-05-30
• First posted: 2022-07-27
• Last updated: 2022-07-27

Locations

1 site across 1 country: Turkey (Türkiye)