NCT05475873

Ondansetron for Postspinal Anesthesia Hypotension

Ondansetron for Postspinal Anesthesia Hypotension in Patients Undergoing Cesarean Section: A Randomized, Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: General Hospital of Ningxia Medical University · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the effectiveness of ondansetron for postspinal anesthesia hypotension in patients undergoing cesarean section.

Detailed description

Post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. The incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. Ondansetron have been highly demonstrated for prevention and/or treatment of post-spinal anesthesia hypotension. However, whether ondansetron could further reduction the incidence of post-spinal anesthesia hypotension is still unknown. The purpose of this study is to investigate the effectiveness of ondansetron for postspinal anesthesia hypotension in patients undergoing cesarean section.

Conditions

• Adverse Effect

Interventions

Type	Name	Description
DRUG	normal saline	A bolus of normal saline (2 ml) by IV was given 5 min before spinal anesthesia.
DRUG	Ondansetron 4 mg	A bolus of ondansetron (2 ml; 4mg) by IV was given 5 min before spinal anesthesia.
DRUG	Ondansetron 8 mg	A bolus of ondansetron (2 ml; 8mg) by IV was given 5 min before spinal anesthesia.

Timeline

• Start date: 2023-06-18
• Primary completion: 2023-10-27
• Completion: 2023-10-27
• First posted: 2022-07-27
• Last updated: 2023-11-02

Locations

1 site across 1 country: China