NCT05474430

Estimating Risk of Respiratory Infections Attributable to CFTR Heterozygosity

Estimating the Risk for and Severity of Respiratory Infections Attributable to CFTR Heterozygosity

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 160 (estimated)
• Sponsor: Philip Polgreen · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: —

Summary

A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays. An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19. The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.

Conditions

• Carrier State
• Respiratory Infections

Timeline

• Start date: 2021-12-20
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2022-07-26
• Last updated: 2026-01-07

Locations

1 site across 1 country: United States