NCT05473338

Complex Regional Pain Syndrome (CRPS) and the Gut-bacteria

Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 250 (estimated)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate, for the first time, whether gut bacteria composition and function of patients with CRPS differ from those of healthy adults. Samples of stool, urine and blood will be collected from patients with CRPS and from healthy adults. The type and function of bacteria of CRPS patients will be analyzed and compared to those of healthy adults to test if potential differences could explain the mechanism/s involved with the development of CRPS.

Conditions

• CRPS

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Stool and blood samples	fecal microbiome and metabolomics, as well as metabolites in plasma
OTHER	Physical examination	physical examination performed by a physician to confirm CRPS diagnosis and assess patient's eligibility to participate in the study. The exam will include skin temperature measured using a laser/infrared skin thermometry.
OTHER	Questionnaires	Questionnaires measuring pain level, sleep, mood and diet parameters.

Timeline

• Start date: 2022-04-14
• Primary completion: 2022-10-14
• Completion: 2024-06-30
• First posted: 2022-07-25
• Last updated: 2022-10-18

Locations

1 site across 1 country: Canada