NCT05473000

Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise

Investigating Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise Based on Resting Ozone Exposure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function. The proposed study aims to have participants perform submaximal and maximal cycling exercise protocols exposed to both O3 and room air in a crossover design to evaluate how ventilatory patterns, pulmonary function, development of symptoms, and cycling performance are impacted by O3 exposure. Additionally, the investigators look to compare responses between O3 at rest and during exercise to predict which subjects may be most susceptible to adverse response, as considerable interindividual variability exists.

Conditions

• Ozone Exposure During Rest and Exercise

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	Submaximal and maximal exercise
OTHER	Ozone	Delivery of ozone air pollution at 170ppb
OTHER	Room air	Delivery of room air

Timeline

• Start date: 2022-08-18
• Primary completion: 2023-06-01
• Completion: 2024-06-01
• First posted: 2022-07-25
• Last updated: 2025-04-13
• Results posted: 2025-04-13

Locations

1 site across 1 country: Canada