NCT05468255

The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults

The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Old Dominion University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

Conditions

• Glucose Intolerance
• Exercise
• Vascular Function

Interventions

Type	Name	Description
OTHER	removal of exercise	Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.

Timeline

• Start date: 2022-07-25
• Primary completion: 2025-01-30
• Completion: 2025-04-01
• First posted: 2022-07-21
• Last updated: 2024-04-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study