NCT05466669

Prediction of Post-TIPS Hepatic Encephalopathy in Patients With Liver Cirrhosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 83 (estimated)
• Sponsor: Johannes Gutenberg University Mainz · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Prediction of hepatic encephalopathy after insertion of a transjugular intrahepatic portosystemic stent shunt (post-TIPS HE) are critical for patient selection prior to TIPS insertion, and a currently unmet, clinically highly relevant need. In this prospective multicenter observational cohort study, the investigators aim to evaluate the ability of Stroop EncephalApp and the simplified Animal Naming Test (S-ANT1) in comparison to the goldstandard PHES to predict the occurence of post-TIPS HE in patients with decompensated liver cirrhosis. Moreover, secondary aims of this study include the detection of potential blood based biomarkers for prediction of post-TIPS HE and the predictive value of frailty and quality of life/sleep prior to TIPS insertion.

Conditions

• Hepatic Encephalopathy
• Liver Cirrhosis

Timeline

• Start date: 2022-03-09
• Primary completion: 2025-02-10
• Completion: 2025-02-10
• First posted: 2022-07-20
• Last updated: 2022-07-20

Locations

2 sites across 1 country: Germany