NCT05463887

Personalized Disease Prevention

Personalized Disease Prevention (PDP): A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 721 (actual)
• Sponsor: Glen Taksler · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate whether patients and their providers benefit from an evidence-based decision tool to help prioritize preventive (and select chronic disease management) services based on their potential to improve quality-adjusted life expectancy, individualized for patient risk factors. The study seeks to enroll 600 patients and 60 primary care providers. Half of providers will be assigned to an intervention to utilize the decision tool with approximately 10 high-priority patients each (patients of particular interest to the research study, on whom follow-up outcomes will be collected), and half will be assigned to usual care. Surveys will be administered at baseline and approximately 6 months later; electronic health records data on preventive service utilization will be collected; and optional qualitative interviews may be conducted.

Detailed description

The study will evaluate whether patients and their providers benefit from an evidence-based decision tool to help prioritize preventive services based on their potential to improve quality-adjusted life expectancy, individualized for patient risk factors. This partially-blinded study seeks to enroll 600 patients and 60 primary care providers. Half of providers will be assigned to an intervention to utilize the decision tool with approximately 10 high-priority patients each (patients of particular interest to the research study, on whom follow-up outcomes will be collected) and half will be assigned to usual care. It is hypothesized that quality-adjusted life expectancy will increase by more in high-priority patients who receive the intervention, as compared with a control group. Objectives: Primary objective: To measure whether use of individualized preventive care recommendations is likely to help patients live a longer, healthier life. Secondary objectives: 1. To measure whether use of individualized preventive care recommendations is likely to help patients live a longer life 2. To assess comprehension of the decision tool 3. To assess readiness to change 4. To assess use of shared decision-making 5. To measure outcomes for specific preventive services

Conditions

• Primary Prevention
• Healthy Aging
• Quality of Life
• Decision Support Techniques

Interventions

Type	Name	Description
BEHAVIORAL	Individualized preventive care recommendations (decision tool)	Providers will receive individualized preventive care recommendations (decision tool) for eligible patients, and discuss them with patients using shared decision-making

Timeline

• Start date: 2022-08-05
• Primary completion: 2026-01-31
• Completion: 2026-01-31
• First posted: 2022-07-19
• Last updated: 2026-03-02

Locations

1 site across 1 country: United States