NCT05462834

Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Sleep disordered breathing is associated with impaired glucose tolerance and incident diabetes. Nocturnal hypoxemia is a potential stimulus of glucose intolerance. It is especially severe and highly prevalent in high altitude residents. Intervening on nocturnal hypoxemia may therefore improve glucose control and decrease the public health burden in high altitude populations. The objective of this study is to examine the impact of hypoxemia on glucose homeostasis in high altitude residents. The investigators will address this objective by examining the effect of supplemental oxygen on glucose in a randomized cross-over study.

Conditions

• Sleep-Disordered Breathing
• Glucose Intolerance

Interventions

Type	Name	Description
OTHER	Compressed Air	Participants will be instructed to use compressed air during sleep as a placebo control.
OTHER	Supplemental Oxygen	Participants will be instructed to use supplemental oxygen at rate of 2lpm during sleep.

Timeline

• Start date: 2025-12-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2022-07-18
• Last updated: 2026-01-07