NCT05461781

Distal Radial Access for Primary PCI in STEMI Patients to Prevent RAO

Distal Radial Access for Primary Percutaneous Coronary Intervention in STEMI Patients to Prevent Acute Radial Artery Occlusion

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 512 (actual)
• Sponsor: Beijing Luhe Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized-controlled trial to compare early radial artery occlusion via distal vs. conventional transradial access among ST segment elevation myocardial infarction patients for primary percutaneous coronary intervention.

Detailed description

Conventional transradial access (TRA) is recommended as the default approach for patients undergoing percutaneous coronary intervention (PCI) according to 2018 ESC guidelines. However, radial artery occlusion (RAO) remains the frequent complication, precluding the future use of the radial artery as an access point for repeat coronary recanalization or as a conduit for coronary artery bypass surgery. More than 50% of patients with ST segment elevation myocardial infarction (STEMI) present multiple vascular lesions, of which 50% require reprocessing non-culprit vessels. Therefore, the patency of the radial artery is crucial for STEMI patients. The distal radial access (DRA), located in the anatomical snuffbox or the dorsum of the hand, was introduced as a promising alternative. Three recent RCTs have shown significant reductions of RAO after DRA compared with TRA. Nevertheless, all of them excluded the patients presenting with STEMI. Therefore, we conduct a prospective, single-center, open-label randomized clinical trial to assess the superiority of preventing RAO at 24 h via DRA when compared TRA among STEMI patients for primary PCI.

Conditions

• ST Segment Elevation Myocardial Infarction

Interventions

Type	Name	Description
PROCEDURE	distal radial access	primary percutaneous coronary intervention via distal radial access
PROCEDURE	conventional transradial access	primary percutaneous coronary intervention via conventional transradial access

Timeline

• Start date: 2022-01-05
• Primary completion: 2023-08-30
• Completion: 2023-08-30
• First posted: 2022-07-18
• Last updated: 2025-03-11

Locations

1 site across 1 country: China