NCT05461365

Intranasal Insulin for COVID-19-related Smell Loss

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Universidad Panamericana · Academic / Other
• Sex: All
• Age: 18 Years – 59 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study was to quantify the improvement in olfaction of 27 post-COVID-19 patients, after three intreventions of intranasal insulin during a four week period, with the help of the Threshold, Discrimination and Identification (TDI) score evaluated with Sniffin Sticks®.

Conditions

• Anosmia
• Smell Loss
• Paraosmia
• Hyposmia
• COVID-19

Interventions

Type	Name	Description
DRUG	Insulin	Gelfoam® cottonoids soaked in 40 IU of NPH insulin were placed on the nasal roof (between the nasal septum and the middle meatus) of each nostril. These remained in place for 15 minutes and were later removed. This procedure was performed in three visits one week apart. During the fourth and last visit (one week after the previous visit), olfaction was reevaluated using the measures previously described.

Timeline

• Start date: 2021-01-04
• Primary completion: 2021-11-25
• Completion: 2021-12-20
• First posted: 2022-07-18
• Last updated: 2022-07-18

Locations

1 site across 1 country: Mexico