NCT05458258

Studying Malnutrition And Sarcopenia In Older Adults With Acute Myeloid Leukemia

Investigating The Prognostic Significance Of Malnutrition And Sarcopenia In Older Adults With Acute Myeloid Leukemia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 239 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: —

Summary

This study will explore how malnutrition (poor nutrition/diet) and sarcopenia (a condition that causes a loss of muscle and bone mass) affects study participants over the age of 60 with acute myeloid leukemia (AML) who will receive induction chemotherapy (chemotherapy given as the first treatment to help cancer go into remission) and/or cancer drugs as part of standard care for AML. By studying how these nutritional and skeletal factors, doctors leading this study hope to learn how malnutrition and sarcopenia may be able to predict certain outcomes --such as how long study participants with poor nutrition and muscle loss can live after chemotherapy- for older (age 60+) individuals with AML.

Conditions

• Acute Myeloid Leukemia
• Leukemia, Myeloid

Interventions

Type	Name	Description
DEVICE	Bioelectrical Impedence Analysis Device	A device that helps measure body composition, in particular body fat and muscle mass based on based on the rate at which an electrical current travels through the body.
OTHER	6 Minute Walk Test	Defined as the distance the participant is able to walk in 6 minutes. Participants will be instructed to perform laps from the 0- to 30 minutes mark and back again for a total of 6 min in an outpatient or inpatient setting on a flat, pre-defined course. Participants will be instructed that goal of the test is to walk as far as possible.
DIAGNOSTIC_TEST	Computed Tomography Scans to Measure Skeletal Muscular Index	Computed tomography scans (a type of x-ray) that will measure the skeletal muscular index (the ratio of the muscle in your arms and legs to your height).
DIAGNOSTIC_TEST	Blood Test/Blood Draw	Blood will be drawn through a need inserted into the participant's arm. This blood will be used to measure the participant's nutrition levels.
OTHER	Hand Grip Strength Test	Grip strength in both hands will be measured using an adjustable hydraulic grip strength dynamometer (a device that is gripped to measure hand strength). The best performance of three trials will be selected for each hand, with averages of the left and right hand used in analyses.

Timeline

• Start date: 2023-03-01
• Primary completion: 2025-04-18
• Completion: 2025-04-18
• First posted: 2022-07-14
• Last updated: 2025-04-30

Locations

1 site across 1 country: United States