NCT05454085

Could Bisphenol-A Have a Role in the Etiology of Neural Tube Defects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 92 (actual)
• Sponsor: Sanliurfa Mehmet Akif Inan Education and Research Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Our aim in this study is in patients with a diagnosis of neural tube defect; is the measurement of BPA levels in maternal blood and amniotic fluid.

Detailed description

This prospective observational study was conducted with 92 patients aged 18 - 45 years who had amniocentesis at 15 - 22 weeks of gestation at Bursa Yüksek İhtisas Training and Research Hospital between April 15, 2021 and April 15, 2022. Patients were divided into two groups according to amniocentesis indications. Group 1: patients with abnormal maternal serum screening test or prenatal diagnosis test, patients with abnormal ultrasonography findings (45 patients), Group 2: patients with pre-diagnosis of NTD (47 patients). During the amniocentesis procedure, the first 5cc amniotic fluid and maternal serum samples were collected from the patients. The obtained samples were stored at -80°C until the end of the study. After all samples were collected, BPA values were measured by ELISA method.

Conditions

• Neural Tube Defects
• Bisphenol-A

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Bisphenol-A	measurement of BPA levels in maternal blood and amniotic fluid

Timeline

• Start date: 2021-04-15
• Primary completion: 2022-04-15
• Completion: 2022-04-15
• First posted: 2022-07-12
• Last updated: 2022-07-12

Locations

1 site across 1 country: Turkey (Türkiye)