NCT05453045

Pharmacokinetics and Excretion of Albendazole and Its Metabolites in Saliva

Pharmacokinetics and Excretion of Albendazole and Its Metabolites in Saliva in Healthy Volunteers

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Universidad Nacional de Salta · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This project will develop and assess the feasibility and acceptability of a salive-based assay to monitor adherence to Mass Drug Administration (MDA) campaigns within Soil-transmitted helminthiasis (STH) control programs, evaluating the salive and serum pharmacokinetics of ALBENDAZOLE (ABZ) and its metabolites.The final goal is to obtain a field ready tool for the measurement of adherence to anthelmintic treatment at a community level that serves as a coverage/adherence indicator and a reference standard for other monitoring tools.

Conditions

• Pharmacological Action

Interventions

Type	Name	Description
DRUG	Albendazole	tablet administration after a meal contaning approximate 15 g of fat

Timeline

• Start date: 2022-07-18
• Primary completion: 2022-08-30
• Completion: 2022-12-16
• First posted: 2022-07-12
• Last updated: 2022-07-14