NCT05452382

Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma

Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma; a National Cancer Database Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,607 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.

Conditions

• Appendiceal Cancer

Interventions

Type	Name	Description
PROCEDURE	Partial colecctomy	Segmental resection of appendiceal adenocarcinoma including terminal ileum and cecum
PROCEDURE	Hemicolectomy	Formal right hemicolectomy including terminal ileum, cecum, and ascending colon

Timeline

• Start date: 2005-01-01
• Primary completion: 2019-12-30
• Completion: 2022-07-06
• First posted: 2022-07-11
• Last updated: 2022-07-11

Locations

1 site across 1 country: United States