NCT05451381

Vasopressor Requirements Depends on Sedation Strategy

Vasopressor Requirements During Dexmedetomidine Sedation vs Propofol vs Their Combination (Dexmedetomidine and Propofol) Sedation in Patients After Cardiac Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 356 (actual)
• Sponsor: Anesthesia Research Group UA · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Most of the patients after cardiac surgery need sedation in the iCU. Sedation strategy could impact the incidence of vasopressor use.

Detailed description

Sedating a patient is a complex process, especially after heart surgery. Sedation has a negative hemodynamic effect. This leads to a decrease in blood pressure and increases the frequency and dose of vasopressors used. The choice of drug for sedation may have an impact on reducing the frequency of use of vasopressor therapy. The goal of the research is compare three strategies: propofol ( sedative agent), dexmedetomidine ( selective α2-adrenergic receptor (α2-AR) agonist that is associated with sedative effect) and their combination for sedation after cardiac surgery.

Conditions

• Sedative Adverse Reaction
• Sedation Complication
• Hemodynamic Instability
• Agitation on Recovery From Sedation
• Respiratory Complication

Interventions

Type	Name	Description
DRUG	Propofol	sedation after cardiac surgery
DRUG	Dexmedetomidine	sedation after cardiac surgery
DRUG	Dexmedetomidine and Propofol	sedation after cardiac surgery

Timeline

• Start date: 2017-08-01
• Primary completion: 2022-05-01
• Completion: 2022-05-29
• First posted: 2022-07-11
• Last updated: 2022-07-12

Locations

1 site across 1 country: Ukraine