NCT05448898

The Efficacy of Traditional Chinese Medicine in Olfactory Dysfunction

The Efficacy of Traditional Chinese Medicine in Olfactory Dysfunction: A Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 278 (estimated)
• Sponsor: Eye & ENT Hospital of Fudan University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Studies have demonstrated that patients with olfactory dysfunction could improve the olfactory function after olfactory training. But the efficacy of Traditional Chinese Medicine is unknown.The purpose of this study is to evaluate its efficacy in olfactory dysfunction.

Detailed description

A recent meta-analysis found significant positive effects of olfactory training on the individual subcomponents of odor threshold, discrimination, identification, and the composite TDI score. In addition to the evidenced improvement in olfactory function after olfactory training, this form of treatment carries very little risk of adverse effects, is cheap, and can be administered by the patient. For these collective reasons, olfactory training is an attractive treatment modality. Chinese experts consensus on diagnosis and treatment of olfactory dysfunction in 2017 shown that some evidences proved that Traditional Chinese Medicine treatment would benefit olfactory dysfunction but the evidences is not adequate. Until now, the efficacy of Traditional Chinese Medicine is controversial. This study investigate the efficacy and the safety of Traditional Chinese Medicine and olfactory training as a treatment for patients with olfactory dysfunction.

Conditions

• Olfactory Disorder

Interventions

Type	Name	Description
DRUG	Traditional Chinese Medicine CU Xiu Tang	Oral Traditional Chinese Medicine CU Xiu Tang once a day and repeat and deliberate sniffing of a set of odorants for 20 seconds each at least twice a day for at least 3 months
OTHER	Olfactory Training	repeat and deliberate sniffing of a set of odorants for 20 seconds each at least twice a day for at least 3 months

Timeline

• Start date: 2022-07-15
• Primary completion: 2023-11-30
• Completion: 2023-12-30
• First posted: 2022-07-08
• Last updated: 2022-07-11

Locations

1 site across 1 country: China