NCT05448417

Exploration of Non-invasive High-frequency Oscillations in Human-machine Asynchrony in Healthy Subjects

Exploration of Non-invasive High-frequency Oscillations in Human-machine Asynchrony in Healthy Subjects : a Clinical Crossover Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Guangzhou Institute of Respiratory Disease · Academic / Other
• Sex: All
• Age: 25 Years – 40 Years
• Healthy volunteers: Accepted

Summary

High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually applied to neonatal intensive care treatment, and is currently recommended as a rescue method for neonatal acute respiratory distress syndrome (ARDS) after conventional mechanical treatment fails. ventilation. Non-invasive high-frequency oscillatory ventilation (nHFOV) combines the advantages of HFOV and non-invasive ventilation methods, and has become a research hotspot in this field. Recommended to avoid intubation after failure of conventional non-invasive ventilation therapy. There is a lack of large-scale clinical trials systematically exploring its efficacy for intubation therapy. The increasing clinical application of nHFOV has also enriched its application in the treatment of other diseases. Human-machine asynchrony during non-invasive ventilation will seriously affect its efficacy, but no one has reported on the research related to nHFOV human-machine asynchrony.

Conditions

• Non-invasive Ventilation
• Healthy Subjects

Interventions

Type	Name	Description
DEVICE	Non-invasive high-frequency oscillatory ventilation	Non-invasive high-frequency oscillatory ventilation generates high-frequency pressure fluctuations in the airway caused by the opening and closing of a solenoid valve.
DEVICE	Noninvasive Bilevel Positive Pressure Ventilation	Noninvasive Bilevel Positive Pressure Ventilation

Timeline

• Start date: 2022-07-15
• Primary completion: 2022-12-30
• Completion: 2023-07-01
• First posted: 2022-07-07
• Last updated: 2022-07-07

Locations

1 site across 1 country: China