NCT05448274

The Effects of a Ruminococcus Torques Strain Bacterium in Healthy Adults.

An Intervention Study to Explore Potential Metabolic Effects of Ruminococcus Torques Strain ATCC 27756 in Healthy Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Oluf Pedersen · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

A randomized, placebo controlled crossover study investigating the potential metabolic effects of the naturally occurring gut microbe Ruminococcus torques in healthy, overweight adults.

Detailed description

By analyzing blood samples, indirect calorimetric as well as thermographic assessment of clavicular temperature we want to investigate whether or not the commensal gut bacterium Ruminococcus toqrues strain ATCC 27756 has any metabolic effects in healthy adults. The subjects will recieve the intervention with the live bacterium given through a duodenal feeding tube. The trial is double blinded and placebo controlled using a crossover design. Subjects will be given an intervention with either placebo or Ruminococcus on two different study days with up to six weeks of wash-out between each study day.

Conditions

• Overweight
• Healthy

Interventions

Type	Name	Description
BIOLOGICAL	Placebo	The placebo will consist of solely glycerol-phosphate-buffered isotonic saline.
BIOLOGICAL	Ruminococcus torques	10\^11 live bacterial cells in glycerol-phosphate-buffered isotonic saline

Timeline

• Start date: 2023-05-03
• Primary completion: 2023-09-06
• Completion: 2023-09-14
• First posted: 2022-07-07
• Last updated: 2023-09-21

Locations

1 site across 1 country: Denmark