NCT05447364

Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty

Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty - A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: Thammasat University · Academic / Other
• Sex: All
• Age: 55 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the efficacy of 75 mg of Pregabalin and 150 mg of Pregabalin in postoperative pain control after TKA.

Detailed description

After being informed about the study and potential risks, all patients giving written informed consent will be chosen for eligibility for the study entry. At the day before surgery date, patients who meet the eligibility criteria will be randomized in a double-blind manner (participant and investigator) in a 1:1 ratio to 75 mg of Pregabalin and 150 mg of Pregabalin groups.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
DRUG	Pregabalin 75mg	1 tab of Pregabalin Brillior 75 mg and 1 tab of Placebo
DRUG	Pregabalin 150mg	2 tabs of Pregabalin Brillior 75 mg

Timeline

• Start date: 2021-07-01
• Primary completion: 2023-09-01
• Completion: 2024-03-01
• First posted: 2022-07-07
• Last updated: 2024-04-16

Locations

1 site across 1 country: Thailand