NCT05446181

CLIC1 in Patients Presenting PD

Accumulation of Chloride Intracellular Channel 1 (CLIC1) Protein in Circulating Monocyte in Elderly Patients Presenting Postoperative Delirium and Its Predictable Role of Postoperative Delirium

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 62 (actual)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Conditions

• Hip Fractures
• Hip Disease

Interventions

Type	Name	Description
BEHAVIORAL	Perioperative delirium	Perioperative delirium
PROCEDURE	Hip surgery	Orthopedic hip joint surgery under spinal anesthesia

Timeline

• Start date: 2022-06-27
• Primary completion: 2024-10-30
• Completion: 2024-10-30
• First posted: 2022-07-06
• Last updated: 2024-11-27

Locations

1 site across 1 country: South Korea