NCT05443061

Subcutaneous Nitroglycerin to Prevent Radial Artery Occlusion in Children

Effect of Subcutaneous Nitroglycerin on the Prevention of Radial Artery Occlusion After Radial Artery Catheterization in Pediatric Patients - a Prospective Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 36 Months
• Healthy volunteers: Not accepted

Summary

The primary objective of the study is to evaluate the vasodilative effect of subcutaneous nitroglycerin to prevent radial arterial occlusion(RAO) after removal of the radial arterial catheter in pediatric patients. The hypothesis of this study is that subcutaneous nitroglycerin will decrease the incidence of radial arterial occlusion after radial arterial catheter removal in pediatric patients by increasing the radial artery size. This is a single-center, double-blind, randomized, placebo-controlled study comparing the effect of subcutaneous nitroglycerin and saline on radial artery cannulation and catheter removal in pediatric patients. Prior to the procedure, each patient will be randomized into either the control arm, saline, or the study arm, nitroglycerin.

Conditions

• Arterial Line
• Ischemia

Interventions

Type	Name	Description
DRUG	Nitroglycerin	Subcutaneous nitroglycerin injection to decrease the incidence of radial arterial occlusion after arterial catheter removal in pediatric patients.
DRUG	Normal saline	Subcutaneous normal saline injection to decrease the incidence of radial arterial occlusion after arterial catheter removal in pediatric patients.

Timeline

• Start date: 2022-09-08
• Primary completion: 2025-03-24
• Completion: 2025-03-24
• First posted: 2022-07-05
• Last updated: 2025-04-29

Locations

1 site across 1 country: South Korea