NCT05436730

"Escape" Phenomenon of the Antihypertensive Therapy Efficacy

The Role of Ambulatory Blood Pressure Characteristics, Features of the Structural and Functional Vascular Wall State, the Presence and Severity of Obstructive Sleep Apnea Syndrome in Predicting the "Escape" Phenomenon of the Antihypertensive Therapy Efficacy.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 165 (actual)
• Sponsor: Federal State Budgetary Institution NATIONAL MEDICAL RESEARCH CENTRE OF CARDIOLOGY NAMED AFTER ACADE · Other Government
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

A little attention is paid to the AHT efficacy escaping problem, which can be explained by the AHT correction simplicity and rapid achievement of the target BP level. Nevertheless, modern statistic data on the effective AH treatment described above let us assume that AHT correction is either totally absent or is untimely in case of the "escape" phenomenon development. This could be one of the main reasons for the high prevalence of ineffective AH treatment. The aim of this study is to determine AHT efficacy "escape" phenomenon timeline and its predictors in hypertensive patients.

Conditions

• Arterial Hypertension

Interventions

Type	Name	Description
DEVICE	Ambulatory blood pressure measurement device	Assessment of the 24-h blood pressure profile
DEVICE	Sphygmocor	Assessment of the arterial stiffness
DEVICE	VaSera-VS	Assessment of the arterial stiffness
DEVICE	Somnocheck	Assessment of the sleep breath disturbances

Timeline

• Start date: 2015-09-29
• Primary completion: 2016-12-30
• Completion: 2025-12-30
• First posted: 2022-06-29
• Last updated: 2022-06-29

Locations

1 site across 1 country: Russia