NCT05434494

The Effect of Remifentanil on ED95 of Remimazolam for Loss of Consciousness in Adult Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 19 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study prospectively uses the biased coin technique to investigate the effect of concomitant administration of remifentanil on the 95% effective dose of intravenous remimazolam (Effective dose 95 \[ED95\]) required for loss of consciousness during anesthesia induction. .

Conditions

• Remimazolam

Interventions

Type	Name	Description
DRUG	Remimazolam	Remimazolam is injected for 30 seconds and the experimental dose will be determined according to the biased coin design up-and-down sequential method. If loss of consciousness is successful, the dose of the next intravenous dose of the next study subject will be reduced from the previous dose with a probability of 1/19 or the same as the previous dose with a probability of 18/19.
DRUG	remifantanil	25cc infusion drug will be prepared (labeled as test drug) and infused with TCI mode. The target effect site concentration is 2.0 ng/ml.

Timeline

• Start date: 2022-07-01
• Primary completion: 2023-07-30
• Completion: 2023-08-31
• First posted: 2022-06-28
• Last updated: 2022-06-28