NCT05434403

Transauricular Vagus Nerve Stimulation in the Treatment of Chemotherapy-induced Peripheral Neuropathy

Transauricular Vagus Nerve Stimulation in the Treatment of Chemotherapy-induced Peripheral Neuropathy: A Randomized Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (estimated)
• Sponsor: Peking University People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Chemotherapy induced peripheral neuropathy is common in tumor patients receiving chemotherapy. Nowaday, CIPN is mainly treated with drugs, but the therapeutic effect is not satisfactory. Previous studies have found that inflammatory immune mechanism plays an important role in neuropathic pain. Vagus nerve stimulation can not only relieve pain by regulating the autonomic nervous system, but also participate in the immune response. Investigators hope that the treatment by vagus nerve electrical stimulation through ear skin can improve the pain and neurotoxicity scores of CIPN patient.If it is proved that vagus nerve stimulation can effectively treat CIPN, it will become a simple and safe non-drug treatment which has good application prospects.

Conditions

• CIPN
• Chemotherapy-induced Peripheral Neuropathy

Interventions

Type	Name	Description
DEVICE	Vagus nerve stimulation	vagus nerve electrical stimulation through ear skin
DEVICE	sham vagus nerve stimulation	sham vagus nerve electrical stimulation through ear skin

Timeline

• Start date: 2022-06-02
• Primary completion: 2022-08-01
• Completion: 2022-11-01
• First posted: 2022-06-28
• Last updated: 2022-06-28

Locations

1 site across 1 country: China