NCT05430503

Long COVID and Post-exertional Pulmonary Diffusion

Lung Diffusing Capacities for Nitric Oxide and Carbon Monoxide in Long COVID With Dyspnea at Rest and After Mild Exercise

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 32 (actual)
• Sponsor: IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Aim of investigators was to study whether abnormalities of lung diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) in long COVID may have a clinical impact in relation to exercise intolerance.

Detailed description

Prolonged recovery from acute coronavirus disease 2019 (long COVID) is characterized in about 30% of subjects from breathlessness and fatigue also during daily activities often associated to decreased lung diffusing capacity for carbon monoxide (DLCO) at rest. Aim of investigators was to study whether abnormalities of lung diffusing capacity for nitric oxide (DLNO) and DLCO in long COVID may have a clinical impact in relation to exercise intolerance. Combined DLNO and DLCO were simultaneously measured at rest and immediately after a short bout of treadmill walking in 32 dyspneic subjects ≥3 months after the COVID-19 acute phase. A group of healthy subjects served as a control group.

Conditions

• Long COVID
• Breathlessness
• Exercise Intolerance
• Alveolar Lung Disease
• Pulmonary Gas Exchange

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Lung volumes, spirometry and standard single-breath DLCO were measured at rest while combined DLNO and DLCO were measured at rest and post-exercise	DLNO and DLCO were measured at rest and 5-10 s after a bout of treadmill exercise simulating usual walking

Timeline

• Start date: 2022-05-24
• Primary completion: 2022-06-15
• Completion: 2022-06-15
• First posted: 2022-06-24
• Last updated: 2022-06-24

Locations

1 site across 1 country: Italy