NCT05425615

Language Processing and TMS

Probing Language Processes Using Transcranial Magnetic Stimulation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 135 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.

Detailed description

To examine the brain's structure and specific language function and interactive relationships, investigators will implement repetitive or rapid TMS protocols in an active (or sham)-controlled, within-subject, randomized studies. Aims will evaluate the effects of short-term changes on each of the semantic or phonological language process of interest in isolation and changes in the interaction between language sub-processes and their interaction with other cognitive domains that directly or indirectly affect language functions. The brain targets for TMS application will be informed by existing evidence on (correlational but not causal) associations between language regions and specific language processes from numerous prior neuroimaging (e.g., functional magnetic resonance imaging or fMRI) and neuropsychological studies. Healthy individuals and/or stroke survivors with aphasia will be recruited to address these aims.

Conditions

• Stroke
• Aphasia
• Language

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation	Deymed DuoMag XT-100 rTMS

Timeline

• Start date: 2024-06-05
• Primary completion: 2032-06-01
• Completion: 2032-06-01
• First posted: 2022-06-21
• Last updated: 2025-05-11

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study