NCT05419232

COVID-19 Vaccine Uptake Trial

RADx Up Safe Return to Schools: Strategies to Increase Vaccine Uptake

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 262 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The goal of this study is to assess the best COVID-19 vaccine uptake strategy among students, staff and household members that have not been vaccinated. There is a multitude of recommendations present that highlight different vaccination strategy; however, it is still unclear which strategy is best to increase COVID-19 vaccination rates. We will compare the effectiveness and acceptance of two different communication strategies among unvaccinated students, staff, and their household members.

Detailed description

A sequential multiple assignment randomized trial (SMART) will be conducted to assess two strategies to increase COVID-19 vaccine uptake. The two strategies that will be assessed are a text message with a link to an information website and peer-based motivational interview. If individuals do not seek vaccination after the first intervention, they will again be randomized into the same two interventions. This will allow for testing of both interventions as well as understanding if the use of a more intense intervention (two 'doses') is optimal for vaccine uptake. In addition, SARS-CoV-2 saliva-based testing will be conducted among students, staff, and household members from the summer of 2022 through the first semester of the 2022-2023 school year. As the pandemic is in its third year, the use of testing among students, staff, and their household members will be assessed Individuals are eligible to be tested multiple times and the testing will occur along different timelines.

Conditions

• Vaccination Refusal
• COVID-19

Interventions

Type	Name	Description
OTHER	Short Message Service (SMS) + Website Link Strategy	The intervention we are evaluating is the effectiveness of a participant receiving a SMS + Website Link as a vaccine uptake strategy
OTHER	Phone Call with Peer Strategy	The intervention we are evaluating is the effectiveness of a participant having a phone call with a peer as a vaccine uptake strategy

Timeline

• Start date: 2022-07-15
• Primary completion: 2023-12-31
• Completion: 2024-05-31
• First posted: 2022-06-15
• Last updated: 2025-04-10
• Results posted: 2025-04-10

Locations

8 sites across 1 country: United States