NCT05417659

Glycogen and Appetite

The Effect of Suppression of Adipose Lipolysis on GLP-1 and Energy Intake in Men and Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Bath · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Obesity is the outcome of chronic excessive energy intake and reduced energy expenditure leading to energy imbalance. It is a risk factor for many preventable diseases such as metabolic disease and its consequences such as type 2 diabetes and cardiovascular disease. Sedentary adults have been shown to have an increased appetite in excess of energy requirements and adults who are more active are able to better regulate energy intake. It is thought that carbohydrate availability and specifically hepatic glycogen utilisation during exercise is a regulator of appetite. However, the majority of research so far does not support this theory, potentially due to research not examining the tissue-specific link between glycogen use and appetite. The aim of this study is to assess whether altering substrate utilisation during exercise by suppressing lipolysis influences GLP-1 levels and caloric intake post exercise. Additionally, the study will explore if there is a tissue specific link between substrate utilisation and post exercise energy intake and examine potential sex differences.

Conditions

• Energy Intake

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Exercise plus carbohydrate	A high carbohydrate drink to be consumed 1 hour prior to exercise and every 15 minutes during exercise.
DIETARY_SUPPLEMENT	Exercise plus niacin	A dose of niacin to be consumed 30 minutes prior to exercise, at onset of exercise and 30 minutes into exercise.
OTHER	Placebo	A placebo drink to be consumed 1 hour prior to exercise and every 15 minutes during exercise and placebo tablets to be consumed 30 minutes prior to exercise, at the onset of exercise and 30 minutes into exercise.

Timeline

• Start date: 2022-10-10
• Primary completion: 2024-03-15
• Completion: 2024-08-30
• First posted: 2022-06-14
• Last updated: 2025-03-27

Locations

1 site across 1 country: United Kingdom