NCT05409729

Subclinical Hypothyrodism and Ovarian Reserve

Evaluation of Ovarian Reserve in Women With Subclinical Hypothyrodism in Reproductive Age

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 13 Years – 45 Years
• Healthy volunteers: —

Summary

This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve Primary outcome: Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)

Detailed description

Thyroid dysfunction is one of the commonest disorders in women of reproductive age .there is association between subclinical hypothyrodism and infertility and ovarian reserve .It's known that subclinical hypothyrodism can be associated with reduced ovarian reserve in women more than 35 years old .Aclear association between subclinical hypothyrodism and ovarian reserve not established in reproductive age in women less than 35 .This retrospective study investigate serum thyroid hormone /Antithyroid hormone ,ovarian reserve markers (basal FSH,AMH,Antral follicle count on day 2-4/prolactin level .

Conditions

• Fertility Disorders

Interventions

Type	Name	Description
BEHAVIORAL	retrospective charts reviewing

Timeline

• Start date: 2016-01-01
• Primary completion: 2020-01-01
• Completion: 2023-08-01
• First posted: 2022-06-08
• Last updated: 2022-06-08

Locations

1 site across 1 country: Egypt