NCT05408728

Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome

Dietary Sugar Hyper-absorptive Intestinal Phenotype as a Predictor of Weight Loss Post-bariatric Surgery

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 52 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.

Conditions

• Obese
• Healthy
• Bariatric Surgery Candidate

Interventions

Type	Name	Description
PROCEDURE	Endoscopic biopsy	Upper small intestinal biopsies from patients undergoing BS will be collected during routine standard of care screening EGD and again from the same patients at 1 year during routine standard of care surveillance EGD (esophageal reflux screening/surveillance). Biopsy-derived enteroid cultures and tissue samples from pre- and one-year post BS will be examined for expression level of sugar transporters and gluconeogenic enzymes; glucose and fructose absorption

Timeline

• Start date: 2022-07-10
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2022-06-07
• Last updated: 2025-09-10

Locations

1 site across 1 country: United States