NCT05406297

Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients

Impact of Trimethylamine N-oxide (TMAO) Serum Levels on Index of Microcirculatory Resistance (IMR) in Patients Diagnosed With ST-Elevation Myocardial Infarction (STEMI)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 400 (actual)
• Sponsor: Lithuanian University of Health Sciences · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: —

Summary

Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO may increase risk of atherosclerotic cardiovascular disease (ASCVD). However, to our knowledge, no data is available on its impact on coronary microcirculation.

Conditions

• STEMI - ST Elevation Myocardial Infarction
• Microvascular Coronary Artery Disease

Interventions

Type	Name	Description
PROCEDURE	pressure-temperature sensor guidewire-based measurement	In brief, a 6-F angioplasty guiding catheter without side-holes will be used first used to engage the left main coronary artery. A pressure-temperature sensor guidewire ( PressureWire™ X Guidewire) will be used for physiology measurements including IMR measurements. Pressure measurement from the wire was first equalized with that of the guiding catheter. Then the pressure sensor will be positioned two-thirds of the way down the LAD artery. Intracoronary nitroglycerin will be administered (100 to 200 μg). Hyperemia will be induced with adenosine intracoronary injections.

Timeline

• Start date: 2021-01-12
• Primary completion: 2022-07-01
• Completion: 2022-08-01
• First posted: 2022-06-06
• Last updated: 2022-08-16

Locations

1 site across 1 country: Lithuania