NCT05406037

Biomarkers for Invasive Mucormycosis

Diagnostic Marker of Mucormycosis : Development and Evaluation of a Diagnostic Assay on a Cohort of Sera

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 3 Years – 64 Years
• Healthy volunteers: Accepted

Summary

Mucormycosis (MM) is one of the main invasive fungal infection (IFI), and is determined by filamentous fungi belonging to the order of Mucorales, with a mortality rate ranging from 20 to 60% according to localization. Prompt initiation of adequate antifungal therapy is critical for treating mucormycosis. Early diagnostic is therefore essential. The presence in the Mucorales' cell wall of uncommon monosaccharides open interesting perspectives for the development of specific diagnostic biomarkers. This study evaluate a diagnostic test for mucormycosis in a cohort of patients with MM and in control groups (high-risk patients without MM and patients with another IFI).

Conditions

• Mucorales Infection
• Mucormycosis

Interventions

Type	Name	Description
BIOLOGICAL	Venous sample	at Day 0, Day 3, Day 7, Day 14, Day 28 (7 ml blood sample collecting on dry tube) D0 = Diagnostic day

Timeline

• Start date: 2023-11-29
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2022-06-06
• Last updated: 2025-12-26

Locations

1 site across 1 country: France