NCT05404373

Treatment Duration on Normobaric Hyperoxia in Acute Ischemic Stroke

The Efficacy and Safety of Normobaric Hyperoxia on Treatment Duration for Acute Ischemic Stroke Patients With Endovascular Treatment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Capital Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Normoxia Hyperoxia (NBO) is a neuroprotective approach that can be implemented early. NBO is simple and non-invasive and can be used at home or in an ambulance to ensure the shortest possible time after cerebral ischemia occurs. The previous study by the investigators suggested that NBO therapy in the early stage of cerebral ischemia has a neuroprotective effect on ischemic brain injury. Although the neuroprotective effect of NBO has been demonstrated, the optimal duration of treatment for NBO to exert neuroprotective effect is still unclear. Therefore, further discussion of the duration of NBO treatment will contribute to the clinical application of NBO and provide a definite theoretical basis for the treatment of cerebral infarction.

Conditions

• Stroke, Acute
• Neuroprotection
• Endovascular Treatment

Interventions

Type	Name	Description
OTHER	Normobaric Hyperoxia (NBO)	NBO was inhaled as early as possible before revascularization, and inhaled for 1h/2h/4h according to different groups
OTHER	Low flow oxygen	immediately given oxygen inhalation at a ventilation rate of 1L/ min using a oxygen storage mask and keep giving oxygen for 4 hours.

Timeline

• Start date: 2022-06-20
• Primary completion: 2023-09-30
• Completion: 2023-09-30
• First posted: 2022-06-03
• Last updated: 2023-12-06

Locations

1 site across 1 country: China