NCT05404230

Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities

Prevention of Oxaliplatin-induced Peripheral Neuropathy - a Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Vejle Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.

Detailed description

The primary objective of the present study is to examine if a high dosage of n-3 PUFA reduces the incidence and severity of chemotherapy-induced peripheral neuropathy (CIPN) 8 months after adjuvant oxaliplatin following surgery for high-risk colorectal cancer. An additional aim is to investigate whether n-3 PUFAs have an effect on nutritional status, cognition and mental status. Inflammatory mechanisms and biomarkers of CIPN in skin biopsies and in blood will be explored.

Conditions

• Peripheral Neuropathy
• Colorectal Cancer

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fish oil	Fish oil containing poly unsaturated fatty acids.
DIETARY_SUPPLEMENT	Corn oil	Corn oil

Timeline

• Start date: 2022-07-15
• Primary completion: 2026-05-01
• Completion: 2026-12-01
• First posted: 2022-06-03
• Last updated: 2026-04-03

Locations

1 site across 1 country: Denmark