NCT05402839

Screening of Malignant Hyperthermia Susceptible Individuals

Molecular Genetics Study on Screening of Malignant Hyperthermia Susceptible Individuals

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: 0 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

This study intends to target patients who underwent surgery under general anesthesia during the study period and developed malignant hyperthermia during or after surgery. Therefore, the total sample size was estimated to be about 50 people based on the past incidence of this rare disease. Every year, about 20 patients and their families who developed malignant hyperthermia during or after surgery will participate in this nationwide study (estimated by the current incidence of malignant hyperthermia), and about 1-5 patients will be admitted to Peking University Third Hospital participate in this research. Relevant specimens were collected from malignant hyperthermia (MH) patients and their family members for genetic analysis to determine the mutation of MH-related pathogenic gene loci.

Conditions

• Malignant Hyperthermia

Timeline

• Start date: 2022-02-22
• Primary completion: 2041-02-01
• Completion: 2041-02-01
• First posted: 2022-06-02
• Last updated: 2022-06-02

Locations

1 site across 1 country: China