NCT05402462

Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

to determine the prevalence and distribution of esophageal motility disorders in NCCP patients who presented after a negative cardiac evaluation and underwent esophageal manometry, esophageal pH monitoring

Detailed description

Non-cardiac chest pain (NCCP) is defined as recurrent anginalike pain without evidence of cardiac disease \[1\]. NCCP is a common disorder and accounts for 14-33% of patient visits to gastroenterologists \[2\]. These patients frequently undergo testing for reflux and esophageal motility as gastroesophageal reflux disease (GERD) is seen in 50-60% and esophageal motility disorders in 15-18% of the patients \[3,4\]. Nutcracker esophagus was thought to be the classic manometric finding in NCCP \[5\] but other studies have reported ineffective esophageal motility (IEM) as the most common motility disorder in NCCP \[6,7\]. Furthermore, up to one-third of patients do not have any GERD or motility disorders and are labeled as functional chest pain \[8\]. Suggested causes in these patients include esophageal hypersensitivity \[9\], abnormal cerebral pain processing and psychological comorbidity \[10\]. The clinical predictors of abnormal esophageal function tests in NCCP have not been identified. Identifying these factors would lead to limited use of testing in those with risk factors and faster institution of pain modulator therapy in patients who are most likely to have functional chest pain.

Conditions

• Esophageal Motility Disorders

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	upper endoscopy	detect esphageal motility disorder by upper endoscopy and esophageal manometry

Timeline

• Start date: 2022-06-30
• Primary completion: 2024-01-30
• Completion: 2024-04-30
• First posted: 2022-06-02
• Last updated: 2022-06-02