NCT05401552

Phosphate Bioavailability Hormonal Response to a Breakfast Meal in Healthy Humans

The Impact of Phosphate Bioavailability on the Hormonal Response to a Breakfast Meal in Healthy Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Clinical Evaluation Research Unit at Kingston General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Convenience food is enhanced with phosphate additives in order to modify taste and texture and for preservation. The purpose of this study is to measure the response of phosphate-related hormones to two different types of breakfast meals that contain the same amount of phosphate but in different forms. This study is a cross-over design.

Detailed description

In the first meal, the participant will consume a standard convenience breakfast meal comprised of a cheese tea biscuit and two Eggo waffles. The amount of phosphorus contained in this meal is 700 mg and the majority of this phosphate would be in the form of phosphate additives. Urine and blood will be collected before and after consumption of the meal to measure how the body responds to the meal. Specifically, levels of phosphate, calcium, creatinine (measure of kidney function) and three hormones involved in phosphate regulation (parathyroid hormone, fibroblast growth factor-23 and vitamin D) will be measured in each blood sample. Creatinine, calcium and phosphate will be measured in each urine sample. The second meal will also contain 700 mg of phosphorus and similar caloric content but in a healthy breakfast meal that does not contain any phosphate additives, consisting of one cup of All-Bran breakfast cereal with milk and a piece of fruit. The same blood and urine tests will be assessed after the second meal.

Conditions

• Phosphate Overload

Interventions

Type	Name	Description
OTHER	Meal	Comparison of two breakfast meals containing the same amount of phosphorus but one in the form of inorganic additives

Timeline

• Start date: 2018-05-11
• Primary completion: 2018-09-01
• Completion: 2018-09-01
• First posted: 2022-06-02
• Last updated: 2022-06-02

Locations

2 sites across 1 country: Canada