NCT05398627

Neurofeedback for Borderline Personality Disorder

Amygdala rtfMRI Neurofeedback for Borderline Personality Disorder

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Kymberly Young · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as an intervention for borderline personality disorder.

Detailed description

We will assess the treatment effects of real-time fMRI neurofeedback in adults with borderline personality disorder. This is an experimental longitudinal design where participants will be followed every two weeks after receiving 2 sessions of neurofeedback from the amygdala . Procedures involve a battery of self-report measures, fMRI and psychophysiological indices (heart rate, respiration).

Conditions

• Borderline Personality Disorder

Interventions

Type	Name	Description
DEVICE	Amygdala Neurofeedback	real-time feedback on the hemodynamic response of the amygdala during positive autobiographical memory recall

Timeline

• Start date: 2022-09-02
• Primary completion: 2026-04-30
• Completion: 2026-04-30
• First posted: 2022-06-01
• Last updated: 2025-11-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study