NCT05398133

Phenotype Assessment of Blood and Airway Eosinophils in Patients With COPD and Asthma

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 36 (estimated)
• Sponsor: Medical University of Warsaw · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Around 1/3 of patients with COPD have elevated eosinophil levels. However, the role of eosinophils in COPD has not been yet understood and is probably different in COPD and in asthma. The aim of this study was to assess the expression of selected surface markers on eosinophils and to assess the gene expression in eosinophils in COPD and asthma patients. We are planning to enrol 12 COPD, 12 asthma and 12 control subjects. Patients will undergo routine clinical assessment, spirometry, blood sampling and sputum induction. Eosinophils will be isolated from blood and sputum. Surface markers on eosinophils will be assessed in flow cytometry, gene expression will be assessed by RNAseq.

Conditions

• COPD Asthma
• Eosinophilic Asthma

Timeline

• Start date: 2020-09-01
• Primary completion: 2022-06-01
• Completion: 2022-06-01
• First posted: 2022-05-31
• Last updated: 2022-05-31

Locations

1 site across 1 country: Poland