NCT05398042

Ketone Administration During Inactivity and Retraining

Effect of Oral Ketone Administration During Inactivity-induced Muscle Atrophy and Retraining-induced Regeneration

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate the effect of oral ketone administration during inactivity-induced muscle atrophy and retraining-induced regeneration. Potential changes in muscle function (cycling performance, knee-extension force and power, jump height) and mass, blood flow and the muscular extracellular matrix will be the main focus. In this context, the dominant leg of the participants (n=24) will be immobilized with a brace for 2 weeks and subsequently retrained in a 4-week progressive resistance exercise training program to stimulate muscle regeneration. During the immobilization and rehabilitation period, participants receive either ketone ester (KE) or placebo (CON). 4 experimental sessions are performed during this time frame in order to evaluate the effects of the trial.

Conditions

• Exercise
• Healthy Male/Female Subjects

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone ester	A daily dose of 3x20g of ketone ester supplementation during a six week intervention period
DIETARY_SUPPLEMENT	Medium Chain Triglyceride (MCT) oil	A daily dose of 3x12.8g of MCT oil supplementation during a six week intervention period

Timeline

• Start date: 2021-12-15
• Primary completion: 2022-06-20
• Completion: 2022-08-31
• First posted: 2022-05-31
• Last updated: 2022-05-31

Locations

1 site across 1 country: Belgium

Regulatory

• FDA-regulated drug study