NCT05397197

Impact of Moderate Preterm Birth on Vocabulary Acquisition

A Longitudinal Study of the Impact of Moderate Preterm Birth on Cortical and Subcortical Processing of Speech Sounds and Vocabulary Acquisition

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Assistance Publique Hopitaux De Marseille · Academic / Other
• Sex: All
• Age: 0 Days – 2 Years
• Healthy volunteers: Accepted

Summary

Children born prematurely may present a neurodevelopmental disorder with a language delay diagnosed as early as 2-3 years of age. This situation is not uncommon: each year in France, approximately 35,000 children are born between 32 and 36 weeks of amenorrhea. In our most recent work, we have shown that moderate premature infants show an attenuated cortical response to a vowel change, suggesting a deficit in the cortical encoding of vowels. This work needs to be continued in order to better understand syllable encoding and identify the neuroplasticity mechanisms underlying early speech encoding. The identification of markers to predict language development is essential for the screening of these children at risk of language delay. These children could thus benefit from early adapted care even before the appearance of language deficits.

Conditions

• Premature Birth

Interventions

Type	Name	Description
OTHER	Electroencephalography	experimental task, neuropsychological evaluation, clinical exam

Timeline

• Start date: 2022-10-19
• Primary completion: 2028-10-19
• Completion: 2030-10-19
• First posted: 2022-05-31
• Last updated: 2026-01-08

Locations

1 site across 1 country: France