NCT05393882

Impact of Cholesterol Level on Long-term Coronary Bypass Graft Patency

Impact of Cholesterol Level on Long-term Angiographic Outcome of Coronary Artery Bypass Grafting

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This single-centre cross-sectional study aims to ascertain the impact of dyslipidemia on long-term graft patency after coronary artery bypass grafting (CABG).

Detailed description

All consecutive patients who underwent CABG from 1st January 2007 to 31st December 2008 at the Prince of Wales Hospital were eligible for entry. Graft patency will be determined by computed tomography coronary angiogram. The severity of stenosis will be classified by the Fitzgibbon classification system. The levels of individual lipid profile subcomponents, namely LDL-C, high-density lipoprotein cholesterol (HDL-C), total cholesterol and triglycerides (TG) will be obtained. A plot of lipid profile subcomponent measurements against time will be compiled and the area under the curve is calculated to estimate gross exposure after CABG. Average lipid exposure is calculated by dividing the gross exposure by the number of days lapsed between the first and last lipid profile measurements. The association between average cholesterol target attainment and graft patency will then be determined.

Conditions

• Coronary Artery Disease
• Bypass Graft Stenosis
• Dyslipidemias
• Bypass Graft Occlusion
• Coronary Bypass Graft Stenosis
• Coronary Artery Stenosis
• Hyperlipidemia
• Hypercholesterolemia

Interventions

Type	Name	Description
RADIATION	Computed tomography coronary angiogram	Preparation * Rate control with oral beta-blockers or calcium channel blockers to achieve the target heart rate of 60 to 70 beats per minute * Sublingual Nitroglycerin to be given on table if not contraindicated, 5 minutes prior to scanning * 18G angiocath at a large antecubital vein for intravenous contrast injection Scanning procedure Contrast CT angiogram (Retrospective gating) * Contrast medium and injection protocol: 75ml Omnipaque 350 with 50ml saline chaser * Automatic triggering started at the aorta of the level of left main coronary artery when the relative reached 100 * Scanning coverage: From the thoracic inlet to diaphragm

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-07-01
• Completion: 2027-12-31
• First posted: 2022-05-26
• Last updated: 2025-03-06

Locations

1 site across 1 country: Hong Kong