NCT05393115

Respiratory Muscle Fatigue at Different Breathing Modes

Does Inspiratory Pressure Wave Form Influence Respiratory Muscle Fatigue and Metabolism During Resistive Breathing

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The study aims at investigating if time to respiratory muscle fatigue and metabolism are influenced by the pressure wave form mode applied during resistive breathing.

Detailed description

In healthy subjects fitted with a nasogastric double balloon catheter and breathing at a resistance, the investigators will measure time to failure, Borg ratings, VO2, VCO2, flow, esophageal-, gastric- and airway-pressure. This will be done during breathing at either a square wave or triangle wave pressure waveform, in random order and trials separated by \>two days. Further respiratory muscle fatigue will be investigated pre and post intervention by maximal esophageal pressure generation (voluntary and with cervical magnetic stimulation).

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Square wave breathing	difference in time to failure from the two breathing modes

Timeline

• Start date: 2021-10-01
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2022-05-26
• Last updated: 2022-05-26

Locations

1 site across 1 country: Denmark