NCT05388396

PIMS-TS in Intensive Care: Retrospective Cohort Trial

Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) in Pediatric Intensive Care: Retrospective Cohort Trial

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 180 (actual)
• Sponsor: Brno University Hospital · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: —

Summary

Pediatric Multisystem Inflammatory Syndrome Temporally associated with SARS-CoV-2, (PMIS-TS) represents the new unit, partially imitating the previously described Kawasaki disease. Due to variable and frequently incomplete clinical presentation together with variable disease severity, the real incidence in pediatric population remains unclear. Currently, PIMS-TS is defined by persistent fever, elevation of inflammatory markers, organ dysfunction (cardiac, central nervous system, respiratory, coagulation, renal, gastrointestinal), skin lesions (exanthematous), and absence of other possible etiology.

Detailed description

During the world COVID-19 pandemic (2020-2022), pediatric patients with PIMS-TS represented a significant part of pediatric intensive care unit (PICU) load. The initial clinical presentation of patients with PIMS-TS could vary significantly, and also due to progressively evolving recommendations, the diagnostic a therapy could vary regionally and over the time too. The aim of this retrospective cohort trial was to describe the initial clinical presentation, diagnostics, therapy and clinical outcome of pediatric patients admitted during 2020-2022 to the one of the 3 university hospital PICUs.

Conditions

• Pims-Ts

Interventions

Type	Name	Description
OTHER	PIMS-TS diagnostic a treatment	PIMS-TS diagnostic a treatment

Timeline

• Start date: 2022-08-01
• Primary completion: 2022-12-31
• Completion: 2023-01-30
• First posted: 2022-05-24
• Last updated: 2023-02-14

Locations

1 site across 1 country: Czechia