NCT05387395

COVID-19 on Disease Activity in Radiologically Isolated Syndrome Cohort

Impact of COVID 19 Vaccination or Infection on Disease Activity in Radiologically Isolated Syndrome Cohort: the VaxiRIS Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 217 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The Radiologically Isolated Syndrome (RIS) is defined as incidental Magnetic Resonance Imaging (MRI) abnormalities fulfil the criteria for dissemination in space, suggestive of multiple sclerosis. Nowadays, mandatory vaccination in patients with multiple sclerosis (MS) is widely recommended. Regarding COVID19, the absence of specific warnings led to the proposal of vaccination in patients with inflammatory diseases of the central nervous system. We aimed to evaluate if COVID19 vaccination or infection increased the risk of clinical conversion to multiple sclerosis or evidence of disease activity (EDA) in a cohort of RIS subjects.

Conditions

• Multiple Sclerosis
• COVID-19

Interventions

Type	Name	Description
OTHER	NO intervention	no intervention

Timeline

• Start date: 2022-05-31
• Primary completion: 2022-07-01
• Completion: 2022-07-01
• First posted: 2022-05-24
• Last updated: 2022-08-01

Locations

1 site across 1 country: France