NCT05385003

Effect of Prebiotics on Hyperuricemia

An Interventional Study for the Beneficial Effects of Prebiotics on Hyperuricemia in Chinese Subjects

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Hyperuricemia is a major risk factor for many chronic diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of Hyperuricemia. Animal studies have demonstrated that administration of prebiotics help delay the progression of Hyperuricemia through several mechanisms. This trial aims to examine its protective effect in humans.

Detailed description

Hyperuricemia is a major risk factor for many chronic diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of hyperuricemia. Animal studies have demonstrated that administration of prebiotics help delay the progression of hyperuricemia through several mechanisms such as reduction in endotoxemia, and enhanced production of short-chain fatty acids. However, whether administration of prebiotics also has a protective effect in subjects with Hyperuricemia remain unknown.

Conditions

• Subjects With Hyperuricemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	anserine	During the study period, subjects are instructed to take one capsule of anserine daily for a total of 3 months. Aside from the prebiotic supplement, all participants are instructed to continue their normal routine and not make any changes to their exercise habits but reduce purine intake.
DIETARY_SUPPLEMENT	Sunflower peptide	During the study period, subjects are instructed to take one capsule of Sunflower peptide daily for a total of 3 months. Aside from the prebiotic supplement, all participants are instructed to continue their normal routine and not make any changes to their exercise habits but reduce purine intake.
DIETARY_SUPPLEMENT	Placebo control	During the study period, subjects are instructed to take one capsule of placebo control daily for a total of 3 months. Aside from the probiotic supplement, all participants are instructed to continue their normal routine and not make any changes to their exercise habits but reduce purine intake.

Timeline

• Start date: 2022-05-14
• Primary completion: 2023-08-31
• Completion: 2023-12-31
• First posted: 2022-05-23
• Last updated: 2022-05-23

Locations

2 sites across 1 country: China